CONSORTIUM
*associated partner
Assistance Publique-Hôpitaux de Paris (AP-HP) is the biggest teaching hospital in Europe, federating 38 different hospitals and groups of hospitals (22,474 beds) mainly located in Paris and its suburban area. It offers advanced treatments to 8M patients per year, including 1.5M hospitalisations (10% of all hospitalisations in France).
As a public health institution, AP-HP pursues 3 main missions: healthcare delivery, medical and paramedical teaching and biomedical and clinical research. AP-HP teams develop high-quality research activities, including European and International Research projects. In particular, AP-HP is involved and/or co-ordinates more than 100 European research projects supported by the Research and Technological Development Research Program from the European Union. AP-HP is also the first biomedical research centre in Europe with > 500 clinical trials per year and > 8,000 publications per year (25% of all medical research publications in France).
APHP is the coordinator of the project and sponsor of the clinical study. The sponsor will be responsible of the general management and will check that the cohort study is conducted in accordance with European and National regulations and guidelines.
Assistance publique - Hôpitaux de Paris (AP-HP)
Clinical Research
Address
55 Boulevard Diderot CS 22305
75610 Paris CEDEX 12
France
Contacts
Prof. Christophe DUVOUX – Coordinator
christophe.duvoux@aphp.fr
Prof. Etienne AUDUREAU - Methodologist / WP 4&5 Leader
etienne.audureau@aphp.fr
Website
https://chu-mondor.aphp.fr
Representatives
Candy Estevez
candy.estevez@aphp.fr
Malika Yahmi
malika.yahmi@aphp.fr
Pierre André Natella
pierre.natella@aphp.fr
The European Clinical Research Infrastructure Network (ECRIN), facilitates multinational clinical research, through the provision of advice and services for the set-up and management of investigator or SME-led clinical studies in Europe. ECRIN unites national networks of clinical trial units across Europe, through its scientific partners, to fulfill its vision of generating scientific evidence to optimise medical practice.
Regulatory and ethical approval and follow-up are led by ECRIN with the participation of AP-HP. This task ensures that all national and international regulatory and ethical requirements are fulfilled before the clinical cohort initiation (i.e., approval by regulatory authorities, independent ethics committees and other appropriate authorities (data protection, etc.) and registration in clinical studies databases (clinicaltrials.gov, etc.).
European Clinical Research Infrastructure Network (ECRIN)
Address
30 Bd Saint-Jacques
75014 Paris
France
Contacts
Amélie Michon
amelie.michon@ecrin.org
Biljana Zafirova
biljana.zafirova@ecrin.org
Website
https://ecrin.org/
Representatives
Amélie Michon
amelie.michon@ecrin.org
Biljana Zafirova
biljana.zafirova@ecrin.org
The University of Luxembourg, founded in 2003 as the first and only public university in the Grand Duchy of Luxembourg, is an international research university with a distinctly multilingual and interdisciplinary character. In 2009, it established its second interdisciplinary centre, the Luxembourg Centre for Systems Biomedicine (LCSB). The LCSB is accelerating biomedical research by closing the link between systems biology and medical research.
LCSB hosts the ELIXIR Luxembourg Node (ELIXIR-LU) focusing on the long-term sustainability of tools and data for translational medicine. ELIXIR-LU aims to “give life” to data for translational medicine, the combination of the clinical and experimental environment. This means optimising the value gained from such data by improving usability and giving them sustainability. As part of this, ELIXIR-LU has established a data hub for translational medicine data to provide controlled access in compliance with the GDPR as a service to the research community. ELIXIR-LU has developed various tools in GDPR-compliant data management and engages strongly in the implementation of ethical principles and data protection concepts in the sharing of sensitive personal data.
University of Luxembourg
(ELIXIR-LU)
Address
Luxembourg Centre For Systems Biomedicine
Campus Belval | BT2
6, avenue du Swing
L-4367, Belvaux
Luxembourg
Contacts
Dr. Venkata Satagopam
venkata.satagopam@uni.lu
Dr. Soumyabrata Ghosh
soumyabrata.ghosh@uni.lu
Website
https://www.uni.lu/lcsb-en/
Social Media
LinkedIn
Representatives
Dr. Venkata Satagopam
Venkata.satagopam@uni.lu
Dr. Soumyabrata Ghosh
Soumyabrata.ghosh@uni.lu
The European Foundation for the Study of Chronic Liver Failure (EF CLIF) is a private non-profit organisation connecting biomedical researchers and healthcare professionals with each other, with patients and patient associations, and with society. The fundamental purpose of EF CLIF, reflected in its founding Statements of 2015, is to advance knowledge and promote research and education in liver disease to improve the prognosis of patients living with chronic liver failure.
The Foundation has made pioneering efforts in conducting a series of large, international prospective studies that have been instrumental in reclassifying the trajectory of patients with chronic liver failure and led to the clinical, prognostic and pathophysiological definition of the syndrome referred to as “acute-on-chronic liver failure” characterized by acute decompensation of cirrhosis, severe systemic inflammation, organ failures, and high short-term mortality. We are inspiring best clinical practices for the management of patients with chronic liver failure and promoting a more sustainable and equitable healthcare system.
Within the EF CLIF, the European Association for the Study of the Liver (EASL) Chair supports research activities through the EASL-CLIF Consortium, a network of 120 tertiary care and university hospitals in 28 European countries. The Grifols Chair promotes translational studies in centres across Europe and North America within the framework of the European Network for Translational Research (ENTR) with 21 centres in 7 countries. Over the last five years, EF CLIF has successfully expanded its geographical scope providing the context to support transcontinental collaborative research projects. The Global Projects chapter, which includes 96 centres in 22 countries, provides the framework to promote research in cirrhosis across the world with the aim to help to build consensus and ensure health equity worldwide.
European Foundation for the Study of Chronic Liver Failure (EF CLIF)
Translational research
Address
Travessera de Gràcia 11, 7th floor
08021 Barcelona
Spain
Contacts
Anna Bosch, PhD
General Manager
anna.bosch@efclif.com
Lidia Garcia-Campmany, PhD
Scientific Communications Manager
lidia.garcia@efclif.com
Website
https://www.efclif.com/
Representatives
Anna Bosch
anna.bosch@efclif.com
Richard Moreau
richard.moreau@efclif.com
Joan Clària
joan.claria@efclif.com
Rajiv Jalan
rajiv.jalan@efclif.com
Cristina Sanchez-Garrido
cristina.sanchez@efclif.com
Pedro Izquierdo-Bueno Martin
pedro.izquierdobueno@efclif.com
Ferran Aguilar
ferran.aguilar@efclif.com
Carlos de la Peña
carlos.delapena@efclif.com
Lidia Garcia-Campmany
lidia.garcia@efclif.com
The Agence de la biomédecine is a national agency established by the 2004 bioethics law. It oversees activities in the fields of organ, tissue and cell procurement and transplantation. It is also competent in the fields of human Medically Assisted Reproduction (MAR), embryology and human genetics. Since December 1st, 2016, it has also been in charge of bio-vigilance and MAR-vigilance.
In the context of the LEOPARD project, the Agence de la biomédecine will contribute with expertise in the fields of kidney transplantation and in allocation algorithms.
Agence de la biomédecine (ABM)
Organ sharing organisations
Address
1 Avenue du Stade de France
93212 Saint-Denis – La Plaine
France
Contacts
Samuel Arrabal
samuel.arrabal@biomedecine.fr
Blandine Derycke
blandine.derycke@biomedecine.fr
Representatives
Istituto Superiore de Sanitá (ISS) is the leading technical and scientific body of the Italian National Health Service and pursues the protection of public health by carrying out research, control, advisory, regulatory and training functions.
The main research activities of the ISS are distributed in 6 Departments, 17 National Centres, 2 Reference Centres, 5 technical-scientific services and a Notified Body for the assessment of the suitability of medical devices. Within ISS, the National Transplant Centre (CNT) acts as the technical body of the Italian Ministry of Health. It was set up under Law 91 of 1999 and, as the National Competent Authority, coordinates all activities regarding procurement, donation, allocation and transplantation of organs; procurement, donation, banking and transplantation of tissues and cells including Medically Assisted Reproduction (MAR) activities; waiting lists of patients.
Centro Nazionale Trapianti (CNT) manages the Transplant Information System, which collects activity data from donation to transplantation of OTC; manages national programs; prepares quality reports; defines protocols about safety and security of organ donation, criteria for organ and tissue allocation. It manages bilateral and multilateral agreements, and promotes information campaigns and training courses.
CNT will participate in all WPs of the LEOPARD project and support ESOT in WP1 activities related to the prospective collection of pre-LT data, including new variables with predictive value. Additionally, CNT is also in charge of the task related to implementing new pre-LT variables with independent predictive value in OSOs pre-LT data sets for large-scale routine collection and real-life validation of LEOPARD models.
Istituto Superiore di Sanitá -
Centro Nazionale Trapianti (ISS-CNT)
Address
Viale Regina Elena 299
00161 Roma
Italy
Contacts
Dr Giuseppe Feltrin
cnt@iss.it
Silvia Trapani
silvia.trapani@iss.it
Representatives
CNT Staff involved in the scientific part of the LEOPARD project:
Giuseppe Feltrin
cnt@iss.it
Silvia Trapani
silvia.trapani@iss.it
Francesca Puoti
francesca.puoti@iss.it
Silvia Testa
silvia.testa@iss.it
Flaminia d’Alessio
flaminia.dalessio@iss.it
CNT Staff supporting financial management and dissemination of the project:
Paola Di Ciaccio
paola.diciaccio@iss.it
Claudia Carella
claudia.carella@iss.it
Organizacion Nacional de Trasplantes (ONT) is a coordinating agency of the Spanish Ministry of Health responsible for coordinating, organizing and overseeing the donation and clinical use of organs, tissues and cells at a national level, in coordination with regional authorities. ONT coordinates all activities regarding the donation, allocation and transplantation of organs, and the management of national waiting lists. It manages national IT systems necessary for its coordinating role, defines guidelines, protocols and procedures to maximize the availability of organs, tissues and cells, and ensures its quality, safety and effectiveness. It fixes parameters for transplant quality assessment, promotes information campaigns for the public, and promotes and develops training courses regarding organ donation. ONT has vast experience in the coordination of national and international initiatives in the field of transplantation (ONT is the Collaborating Center of the World Health Organization and President of the Iberoamerican Network-Council of Donation and Transplantation). It has developed one of the most robust KEPs in Europe.
Moreover, ONT is a member of the SAT and participates in the international KEP developed under the framework of this transnational alliance (KEP-SAT), where ONT is responsible for the IT platform. ONT is or has been participating as coordinator or partner of several EU-funded projects and Joint Actions, among others, ALLIANCE-O, DOPKI, FOEDUS, ACCORD, EQSTB, EUSTITE, EUROCET, SOHOV&S, EURO-GTP II, EFRETOS, TRANSPOSE, EGALITE, EUROTRACTOR.
Organizaión nacional de trasplantes (ONT)
Address
SINESIO DELGADO,
6 - PABELLÓN 3
28029 Madrid
Spain
Contacts
BEATRIZ DOMÍNGUEZ-GIL GONZÁLEZ
bdominguez@sanidad.gob.es
GLORIA DE LA ROSA RODRÍGUEZ
grosa@sanidad.gob.es
Website
www.ont.es
Social Media
Twitter
Representatives
Beatriz Domínguez-Gil
bdominguez@sanidad.gob.es
Gloria de la Rosa
grosa@sanidad.gob.es
Lola Perojo
mperojo@sanidad.gob.es
Eurotransplant is an international non-profit organization responsible for the allocation of donor organs in Austria, Belgium, Croatia, Germany, Hungary, Luxembourg, the Netherlands and Slovenia. This international collaborative framework includes all transplant hospitals, tissue typing laboratories and hospitals where organ donations take place.
Eurotransplant offers an international waiting list and a detailed database with information on both donors and recipients.
Eurotransplant will participate in WP1, WP5 and WP6 of the LEOPARD project, but will not facilitate a coordinating role between our transplant centers and the LEOPARD project regarding data collection (WP1).
Stichting Eurotransplant International Foundation (ET)
Address
Haagse Schouwweg 6
2332 KG Leiden
The Netherlands
Contacts
Dr. Serge Vogelaar
s.vogelaar@eurotransplant.org
Social Media
LinkedIn
Representatives
Dr. Marieke de Rosner – van Rosmalen
m.vanrosmalen@eurotransplant.org
Marijke Zaat
secretariat@eurotransplant.org
Anouk de Jong
a.dejong@eurotransplant.org
The European Liver Patients Association (ELPA) was born out of the collective ambition of various European liver patient groups seeking to exchange their diverse experiences in managing liver diseases across different countries. In June 2004, a coalition of 13 patient groups from 10 European and Mediterranean Basin countries convened, leading to the establishment of ELPA. Its official inauguration took place in Paris on April 14th, 2005, coinciding with the annual conference of the European Association for the Study of the Liver (EASL). Today, ELPA boasts a membership of over 30 groups from 25 countries, serving as a representative body for liver patients, their families, and volunteers.
ELPA’s role in the project is to represent patients’ perspectives and views. We are a crucial part of the communication and dissemination team making sure the project information and results are recognised by the general public and policymakers.
European Liver Patients’ Association (ELPA)
Patient organisations
Address
Place du Champs de Mars 5
1050 Brussels
Belgium
Contact
Marko Korenjak
Marko.korenjak@elpa.eu
Veronika Vsetickova
Veronika.vsetickova@elpa.eu
Website
https://elpa.eu/
Representatives
Marko Korenjak
marko.korenjak@elpa.eu
Veronika Vsetickova
veronika.vsetickovaa@elpa.eu
Transhepate fédération is an association of patients who help people with liver transplants or waiting for a transplantation.
We are also committed to scientific approaches, and also all development in liver transplantation.
We are also recognised in France as a strong association. Member of Greffes +, administrator at the French Biomedicine Agency (ABM).
We are joining the LEOPARD project as a patient association to give the voice of the patient.
Transhepate fédération (TH)
Address
6 Rue de l’Aubrac
75012 Paris
France
Contacts
Eric Buleux-Osmann (president)
Eric.buleux@gmail.com
Website
Transhepate.org
Representatives
ESOT was founded 40 years ago and is dedicated to the pursuit of excellence in organ transplantation. Facilitating a wealth of international clinical trials and research collaborations over the years, ESOT remains committed to its primary aim of improving patient outcomes in transplantation. With a community of over 8,000 members from around the world, ESOT is a highly influential international organisation and the facilitator of the biennial congress which hosts approximately 3,500 experts who come to meet to explore and discuss the latest scientific research. ESOT works with leading transplantation experts and has an impressive track record in supporting research, education, and European policy changes.
The European Society for Organ Transplantation (ESOT)
Scientific societies
Address
Westerdoksdijk 423
1013 BX Amsterdam
The Netherlands
Contacts
Wojciech Polak
w.polak@erasmusmc.nl
Website
https://esot.org/
Representatives
Devi Mey
Chiara Parisotto
Michelle De Guia
University Hospital Leipzig, tertiary medical centre of maximal therapy.
Liver transplantation centre
ACLF Unit
Hepatology standard ward
Haptology out-patient clinic concentrated on viral hepatitis, autoimmune and cholestatic liver diseases, MASLD.
HCC-Therapy Centre
Our Role in Leopard is to collect clinical data of patients. We are also able to collect biobank specimens such as blood, liver biopsies, gut biopsies urine, and stool.
The European Association for the
Study of Liver (EASL)
Address
Liebigstrasse 20
04103 Leipzig
Germany
Contacts
Prof. Dr. Thomas Berg
Thomas.Berg@medizin.uni-leipzig.de
Carolin Kufs
studien-hepatologie@medizin.uni-leipzig.de
Website
www.uniklinikum-leipzig.de
Representatives
Prof. Dr. Thomas Berg
Prof. Dr. Florian van Bömmel
Dr. Jonas Schumacher
Dr. Rhea Veelken
Dr. Eva Messer
Ophiomics is a Portuguese clinical-stage Medtech SME company developing cutting-edge diagnostic products and services integrating bioinformatics, artificial intelligence and genomics in support of diagnostic, prognostic, treatment selection and clinical follow-up in oncology. It was funded by an H2020 call to develop HepatoPredict, an AI-based signature predictive of the recurrence of HCC after LT.
Ophiomics joined the LEOPARD project with several objectives: 1) to evaluate the applicability of the HepatoPredict tool to predict drop-out from the waiting list in HCC candidates enrolled in the LEOPARD prospective cohort, 2) to contribute to the development of an extension of the HepatoPredict approach relying on liquid biopsy, 3) to endorse the exploitation of OMICs signatures validated in the LEOPARD project.
Ophiomics - Investigacao e Desenvolvimento em Biotecnologia SA (OPH)
Address
Rua António Champalimaud lote1, sala 14
1600-514 Lisbon
Portugal
Contacts
José Leal
jleal@ophiomics.com
Joana Vaz
jvaz@ophiomics.com
Website
www.ophiomics.com
Representatives
José Leal (Leading)
jleal@ophiomics.com
Joana Vaz (Leading)
jvaz@ophiomics.com
André Folgado (Team member)
afolgado@ophiomics.com
Ana Chocalheiro (Team member)
achocalheiro@ophiomics.com
Laura Frazão (Team member)
lfrazao@ophoimics.com
Maria Reis (Team member)
mreis@ophiomics.com
Daniela Proença (Team member)
dproenca@ophiomics.com
The Instituto de Investigación Sanitaria La Fe (IIS La Fe) is the biomedical research area created between the Hospital Universitario y Politécnico La Fe, the Universitat de València, the Universidad Politècnica de València, the Consejo Superior de Investigaciones Científicas, the Fundación para la Investigación del Hospital Universitario La Fe de la Comunidad Valenciana and the Fundación IVI. As part of IISLaFe, the Biomedical Imaging Research Group (GIBI230), led by Dr. Luís Martí Bonmatí, is focused on improving medical imaging's diagnostic and therapeutic efficiency through advanced radiomic techniques and biomarker extraction.
In the LEOPARD project, our team plays a central role in constructing a state-of-the-art image repository that integrates HCC data, leading efforts in image harmonization and analysis. Utilizing GANs and data augmentation techniques, we craft Radiomics Signatures. Additionally, we oversee the validation of both OMICs and radiomics signatures generated
Fundación para la Investigación del Hospital Universitario la Fe de la Comunidad Valènciana (HULAFE)
Address
AV FERNANDO ABRIL MARTORE,
Nº 106
VALENCIA, SPAIN
46026
Contacts
Luis Marti Bonmati
marti_lui@gva.es
Website
http://www.iislafe.es/
Representatives
Serena Pisoni
serena_pisoni@iislafe.es
Ana Penadés Blasco
ana_penades@iislafe.es
Leonor Cerdá Alberich
leonor_cerda@iislafe.es
Rocío Catalán Flores
rocio_catalan@iislafe.es
Alexandre Pérez Girbés
perez_alegir@gv
FINOVATIS is a French consulting company, owned by EPSA and based in Lyon. We specialise in the funding, management and promotion of national and international research projects and networks. We provide complementary expertise (managerial, financial, fiscal, technical and scientific) to assist academics, research institutes, private companies, associations and industrial partners in running their projects.
Role in LEOPARD:
FINOVATIS is mainly involved in work package 7 to assist the Coordinator at AP-HP in the management activities of the project such as:
Offering a permanent helpdesk for project participants
Following up on deliverables and milestones
Providing assistance in generating the periodic reports to the EU (technical & financial parts)
Providing support for contractual aspects
Advising on EU rules and procedures
Supporting the preparation of project meetings
FINOVATIS is also involved in the communication and dissemination activities of the LEOPARD project, providing support to ESOT as work package 6 Leader.
Finovatis (FIN)
Address
62 rue de Bonnel
69003 Lyon
France
Contacts
David KOUBI
david.koubi@finovatis.com
Maud LE GRAET
maud.legraet@finovatis.com
Sebastien DEGOT
sebastien.degot@finovatis.com
Website
https://finovatis.com/
Social Media
LinkedIn
Representatives
Maud LE GRAET
Project Manager
maud.legraet@finovatis.com
Sebastien DEGOT
sebastien.degot@finovatis.com